Technological advancements in medical imaging techniques are opening new possibilities for diagnostics and monitoring health conditions. This study aimed to develop and evaluate a portable ultrasound-impedance tomograph designed for long-term monitoring of the lower urinary tract. This device combines ultrasound and impedance technologies, enhancing imaging accuracy and the non-invasiveness of procedures, which is particularly crucial for patients requiring regular examinations. The study used a prototype tomograph on patients with lower urinary tract disorders. To assess the device's effectiveness, images obtained from traditional diagnostic methods were compared with those generated by the new tomograph. This device utilizes advanced ultrasound beamforming technology and multiplexing of measurement channels, allowing for rapid and accurate diagnostics without requiring invasive sensor placement within the patient's body. The findings indicate that the newly developed tomography provides high-resolution and high-contrast images, facilitating better pathology identification than traditional methods. It was also demonstrated that the device effectively monitors changes over time, crucial for planning long-term treatment and monitoring patients. The development of this device opens new possibilities in diagnosing and monitoring medical conditions, enabling more precise and less burdensome diagnostic procedures. Its application could significantly improve the quality of life for patients and the efficacy of therapies in urology and other medical fields.